187, 238248 (2004). Contact Dermatitis. The material is rapidly converted from a liquid to a solid state via polymerization at room temperature without the need for a catalyst, evaporation of a solvent or application of pressure [5]. Eczema types: Contact dermatitis diagnosis and treatment. xref Polym. Seo JH, Lee DH (2008) Patient satisfaction with a tissue adhesive in preauricular fistulectomy. Published online by Cambridge University Press: Blanchet, Nadia Given the case history, the patient was likely sensitized to Dermabond from prolonged exposure to embedded Dermabond from a previous procedure. Off-label medical use was widespread in many surgical specialties and dentistry by the 1980s especially throughout Europe. Except for Nakagawa et al., our incidence of 2.7% is somewhat higher than the previously reported incidence, but studies to date alone cannot clarify whether this is due to the difference in application site or patient demographics. 0000016211 00000 n 0000014217 00000 n 1 These findings were practice-changing for the senior author (N.B. 2014. Hysterectomy Defined Hysterectomy Facts Laparoscopic Hysterectomy Vaginal Hysterectomy Abdominal Hysterectomy Robotic . Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Singer, A. J. et al. Allergy Clin. 2021GR145), 1167 patients who underwent skin closure with topical skin adhesives in our institution between April 2017 and February 2021 were investigated for study eligibility. Allergic Contact Dermatitis to Dermabond Prineo After Elective Orthopedic Surgery. Physician 82, 249255 (2010). Search for other works by this author on: Allergic contact dermatitis after postsurgical repair with 2-octylcyanoacrylate, FDA summary memo: General and Plastic Surgery Devices Advisory Committee (Panel) Meeting, August 25, 2006, A prospective comparison of octyl-2-cyanoacrylate and suture in standardized facial wounds, Use of 2-octyl-cyanoacrylate skin adhesive (Dermabond) for wound closure following reduction mammaplasty: A prospective, randomized intervention study, Ectopic contact dermatitis from ethyl cyanoacrylate instant adhesives, Contact dermatitis to ethyl-cyanoacrylate-containing glue, 10 years of patch testing with the (meth)acrylate series, Foreign body reaction after usage of tissue adhesives for skin closure: A case report and review of the literature, 2009 American Society for Aesthetic Plastic Surgery, Ultrasound Calculation of Fat Volume for Liposuction: A Clinical Software Validation, Opioid Prescribing Patterns in Body Contouring Surgery, Perspectives on Cybersecurity and Plastic Surgery: A Survey of Plastic Surgeons and Scoping Review of the Literature, Alternative Abdominal Wall Plication Techniques: A Review of Current Literature, Repair of Congenitally Defective Type of Earlobe Clefts With Residual Lobular Tissue: A Convenient and Effective Surgical Technique, https://doi.org/10.1016/j.asj.2009.02.019, http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4233b2_01.pdf, Receive exclusive offers and updates from Oxford Academic, Simultaneous Breast Augmentation and Mastopexy. 2015;73(4):195-221. Thus, allergic reactions should only increase as laparoscopic and robotically assisted hysterectomy replace open abdominal and vaginal techniques. Caton AM, Dauphine C (2014) Allergic contact dermatitis after repeated exposure to Dermabond. Over several decades, skin staples and sutures have been regarded as a common method for skin closure. Join Now - Help for Your Hysterectomy Support Needs. The clinical characteristics of patients with allergic contact dermatitis (ACD) due to a skin adhesive containing 2-octyl cyanoacrylate, Dermabond, have not yet been elucidated. If things get worse, tell your doctor - and also if your symptoms haven't subsided after 3 weeks. Habib, Nazia Allergic contact dermatitis due to the liquid skin adhesive Dermabond All incisions were erythematous and pruritic, but not tender. In addition, the sutureless closure has become a marketing tool for surgeons. Therefore, we believe that the presence or absence of a patch test would not have significantly affected the results of the study. 2019. Ronis ML, Harwich JD, Fung R, Dellavecchia M (1984) Review of cyanoacrylate tissue glues with emphasis on their otorhinolaryngological applications. 0000013256 00000 n official website and that any information you provide is encrypted Bowen, C, Bidinger J, Hivnor C, Hoover A, Henning J (2014) Allergic contact dermatitis to 2-Octyl cyanoacrylate. dermabond - allergic reaction | HysterSisters - HysterSisters Hysterectomy This study has two limitations. Would you like email updates of new search results? Surgical history is significant for partial left mastectomy performed two years prior and L5 laminectomy fifteen years before presentation. 2020. 2019 Jan;35(1):75-77. doi: 10.1097/PEC.0000000000000994. This type of rash is usually localized to one or two spots on the body. Characterizing the diagnosis and treatment of allergic contact dermatitis to 2-octyl cyanoacrylate used for skin closure in elective orthopedic surgery. Complications associated with Dermabond during head and neck surgery: MAUDE and literature review. A 47-year-old woman with no known drug allergies underwent uncomplicated bilateral breast reduction. Bitterman A, Sandhu K. Allergic contact dermatitis to 2-octyl cyanoacrylate after surgical repair: humidity as a potential factor. Unauthorized use of these marks is strictly prohibited. Osmond, M. H., Quinn, J. V., Sutcliffe, T., Jarmuske, M. & Klassen, T. P. A randomized, clinical trial comparing butylcyanoacrylate with octylcyanoacrylate in the management of selected pediatric facial lacerations. BMJ Open 6, e009257 (2016). Quinn, J. et al. Upon physical exam, a thin layer of Dermabond remained in place on the epidermis and an erythematous raised wheal (1-3 cm radius) surrounded each incision. DERMABOND ADVANCED Topical Skin Adhesive | Skin Glue | Ethicon Hysterectomy Recovery (post hysterectomy). JAAD Case Rep. 2017;3(6):480-481. 0000009330 00000 n Sharma, A. et al. The next morning, with worsening erythema and itching, she was seen in the emergency room by the surgeon. Hysterectomy is one the most commonly performed surgeries in women in the United States. Type IV Hypersensitivity Reaction to Dermabond (2-Octyl Cyanoacrylate 8 Days Post Hysterectomy Allergic Reaction to Dermabond - Help! ACD was considered as a dependent variable, while age, sex, body mass index, diabetes, smoking, asthma, history of atopic dermatitis, history of contact dermatitis, neutrophil count, eosinophil count, and anatomical region were considered as independent variables. Our case, and the cases reviewed here, highlight the usual temporal presentation of allergic reaction to Dermabond. Diffuse Cutaneous Allergic Reaction to Dermabond, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, Department of Physical Medicine and Rehabilitation, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaUSA, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, https://doi.org/10.1017/S1049023X14001010, Get access to the full version of this content by using one of the access options below. As ACD occurs without risk factors in 23% of patients who used 2-octyl cyanoacrylate or n-butyl cyanoacrylate topical skin adhesives, clinicians and patients should be aware of these facts before using topical skin adhesives. J. Arthroplasty 28, 553556 (2013). Is Fixing Pediatric Nail Bed Injuries With Medical Adhesives as Effective as Suturing? Uda, Hirokazu 39, 13751405 (2014). Extensive exposure to these sources of cyanoacrylate adhesives should be investigated before the decision is made to use Dermabond for surgical skin closure as they may predispose the patient to allergic reaction. 0000003027 00000 n Allergic contact dermatitis due to the liquid skin adhesive Dermabond Ophthalmology 110, 291298 (2003). The dermatologist diagnosed ACD based on history of exposure, morphology (well-demarcated pruritic eczematous eruptions, papules, or vesicles), and regional distribution (localized in the area of skin that was exposed to skin adhesives) (Fig. She was unable to see the surgeon on that day. I had an allergic reaction to dermabond after surgery (lipoma removal-23 incisions between knee and under breasts). All the study protocol were conducted in accordance with the relevant guidelines and regulations (STROBE guidelines)18. Patient demographics are presented in Table 1. Nine patients had positive patch test results to Dermabond; six had developed secondary generalization.The mean time between Dermabond application and ACD onset was 34 days (range, 27-44) in six patients with ACD after the first use, whereas, in the other three patients, it was 5.6 days (range, 4-8) after the second use. Cochrane Database Syst Rev. 0000059825 00000 n Medicinal use of cyanoacrylate adhesives before FDA approval dates to the Vietnam War where field surgeons regularly used the formulation to quickly stop haemorrhage from skin wounds [10]. Durando, D. et al. Federal government websites often end in .gov or .mil. %PDF-1.7 % Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Dermatitis 2016; 27 (2):75. sharing sensitive information, make sure youre on a federal Wound complications after 2-octyl skin closure systems for total joint arthroplasty. 0000010468 00000 n The use of Dermabond for surgical or traumatic wound closure was first approved in the United States by the FDA for human use in 1998. Vesicles similar to those seen with poison ivy were visible throughout all incisions, extending only to the area where Dermabond was applied (Figure 1). Publication types Case Reports MeSH terms Breast Implantation / adverse effects Gorski J, Chuang L (2018) Allergic reaction to Dermabond in gynaecologic surgery. doi: 10.3928/01477447-20200827-01. Three additional trocars were placed in the right lower quadrant, left lower quadrant and at the umbilicus. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Durando, D. et al. Lindstrom I, Suojalehto H, Henriks-Eckerman ML, Suuronen K (2013) Occupational asthma and rhinitis caused by cyanoacrylate-based eyelash extension glues. An area where the Dermabond had dripped on the lateral side of her breast was also erythematous. On postoperative day 13, itching began again laterally and her husband injected a single 40-mg dose of Depo-Medrol (Pfizer Inc., New York). Removal of the Dermabond was attempted, but the incision began to separate. Article Google Scholar Most of these studies have highlighted concerns like allergic reactions following the use of Dermabond Prineo [10, 24,25,26,27,28,29 . The site is secure. Ask your HysterSisters. A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. Oxford University Press is a department of the University of Oxford. Google Scholar. A rash around a surgical incision is fairly common. The monomer polymerizes upon contact with the applicator tip, water, and exposure to body temperatures. 69, 763781 (2012). A case of contact dermatitis syndrome caused by Dermabond, followed by contact dermatitis caused by false eyelash glue and Aron Alpha glue: possibility of cross-reactions among cyanoacrylates. Gearhart, Peter A. A 36-year-old white woman on postoperative day four. The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity. 0000053193 00000 n w5P 6 5N,i5E$3011aeax0d2b fc2ba41q?g+3dQ2 /:+c=2F-x..FDtT81a.Q|,/1E0|b Dermatologist evaluation confirmed the suspicion of an allergic reaction to Dermabond and recommended application of a thin topical layer of hydrocortisone 1% to affected areas 2-4 times per day. This site needs JavaScript to work properly. Wright JD, Herzog TJ, Tsui J, Ananth CV, Lewin SN, et al. First, patch tests were not conducted on all suspected patients to diagnose ACD, so the accuracy of the diagnosis could be doubted. Our community is filled with women who have been through the Hysterectomy experience providing both advice and support from our active members and moderators. It may be from the glue or adhesive used to close the wounds, or from antibiotic ointments applied to the wound to prevent infection. 0000062096 00000 n The chemistry of tissue adhesive materials. Am. 0000017254 00000 n Surg. Despite these advantages and convenience in use, several recent studies have reported complications associated with its use; these are being increasingly reported as the use of the material has steadily increased. Accessibility It. Although cyanoacrylates traditionally have been associated with low rates of sensitization, allergic contact dermatitis (ACD) to Dermabond products is being increasingly reported after orthopedic surgery. 0000003918 00000 n Our community is filled with women who have been through the Hysterectomy experience providing both advice and support from our active members and moderators. sustainable solutions for society. Zwemer, Catherine and Mc Donald BS, Buckley DA (2014) Severe dermatitis from Dermabond surgical glue. Skin inflammation and pruritus abated completely within two days. 0000044744 00000 n You are using a browser version with limited support for CSS. Dunst KM, Auboeck J, Zahel B, Raffier B, Huemer GM (2010) Extensive allergic reaction to a new wound closure device (Prineo). Postoperative results following the resolution of this allergic reaction are shown in Figure 3. In addition, since the agent used for postoperative wound dressing was the same as that used for preoperative skin preparation, the area of the rash or erythema would have been more extensive than that of the topical skin adhesive if the patient was allergic to the dressing agent. We avoid using tertiary references. Orthop. Bone Jt. At-home therapies for eczema and dermatitis. Well go over the causes of an ear keloid before diving into. The AADA recommends emergency care if you have any of these symptoms. This relationship ended in 2005. Cureus. J. Arthroplasty 32, 24312435 (2017). Reconstr. Allergic Contact Dermatitis to Dermabond Prineo After Elective researchers, each embracing the concept that basic knowledge can foster Hysterectomy is the surgical removal of the uterus. Her incisions were closed with Dermabond. Had gallbladder removed in 2009, all good. The surgeon and infectious disease physician agreed that her erythema was an allergic reaction to the Dermabond. In the logistic regression analysis, age, sex, body mass index, diabetes, smoking, asthma, history of atopic dermatitis, history of contact dermatitis, neutrophil count, eosinophil count, and anatomical region did not show any correlation with the occurrence of allergic contact dermatitis (Table 2). Yoshimura, Kotaro Park, Y.H., Choi, J.S., Choi, J.W. Contact Dermatitis. 8600 Rockville Pike 0000061721 00000 n In logistic regression analysis, none of the variables were found to increase the risk of ACD in both 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. Hydrocortisone ointment was prescribed for the rash and to dissolve the Dermabond. Get the most important science stories of the day, free in your inbox. %%EOF hasContentIssue false, Correspondence: Joseph A. Ricci, MD Division of Plastic Surgery Brigham and Women's Hospital 75 Francis Street Boston, Massachusetts 02115 USA E-mail, Copyright World Association for Disaster and Emergency Medicine 2014. The increased prevalence of keloids in atopic dermatitis patients with allergic comorbidities: a nationwide retrospective cohort study, Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis, Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions, Meta-analysis of the efficacy of preoperative skin preparation with alcoholic chlorhexidine compared to povidone iodine in orthopedic surgery, Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers, Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice, Bacterial sensitivity to chlorhexidine and povidone-iodine antiseptics over time: a systematic review and meta-analysis of human-derived data, http://creativecommons.org/licenses/by/4.0/, Contact Dermatitis in the Inpatient Hospital Settingan Updated Review of the Literature. Clin Case Studie Rep 1: DOI: 10.15761/CCSR.1000102. 2014;29(5):1-3. Unable to load your collection due to an error, Unable to load your delegates due to an error. A comparison of three methods of skin closure following repair of Achilles tendon rupture. In rare cases, scratching or otherwise irritating the rash can result in a skin infection. A healthy 36-year-old white woman with a deflated silicone gelfilled breast implant underwent uneventful removal of her implants, bilateral capsulotomies, replacement of her implants with 325-cc silicone gelfilled implants, and bilateral mastopexies. View all Google Scholar citations Hivnor CM, Hudkins ML (2008) Allergic contact dermatitis after postsurgical repair with 2-octylcyanoacrylate. Concerns of tissue toxicity eventually excluded methyl 2-cyanoacrylate from use on human tissue [12]. https://doi.org/10.1038/s41598-021-03319-3, DOI: https://doi.org/10.1038/s41598-021-03319-3. The .gov means its official. To investigate the clinical characteristics of patients with ACD caused by Dermabond application.