No libido It can be reversed yes. (I got my hair transplant at 36). Federal government websites often end in .gov or .mil. : June 21, 2022. An official website of the United States government. What is Post-Finasteride Syndrome? HCG will increase progesterone or will decrease it? In addition, many doctors dont understand or even recognize PFS as a real disease and these patients will suffer alone. These findings suggest that finasteride treatment may have broad consequences for brain function. You may instead use topical minoxidil (Rogaine), which has no known negative effects on male fertility. I stop just about every patient that comes to me on this medication. These symptoms occur in three categories: sexual, physical and neurological. CreGAAtine vs creatine monohydrate: Its not better! Response via Twitter to the Karolinska Institutet study Association of 5-Reductase Inhibitors With Prostate Cancer Mortality: May 31, 2022. What is Post-Finasteride Syndrome? wow very helpful articular and explains my symptoms exactly. Conclusion: This study showed that short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms reported by patients with PFS, likely reflecting the vast array of genes modulated by the AR [and] a U-curvilinear profile of (CAG)n repeats for skin dryness symptoms, where the two extremes exhibited a worse condition than medium repeats. Bring on the BIC! Balding? Epub 2019 Jan 16. What do you think of TRT is PCT to recover from PFS? Delusional disorder of the somatic type; Dutasteride; Finasteride; Histrionic personality disorder; Post-finasteride syndrome. Their only crime in life is to take an FDA-approved drug. Sure I can do that for you. In my opinion, these medications are contraindicated in this population. According to the Post-Finasteride Syndrome Foundation, the symptoms can be physical, mental, neurological, or sexual, and can persist even after you stop taking the medication. I think [Propecia] is a potentially dangerous drug. is a recovery really possible? Low levels of these hormones increase glutamate and may account for the appearance of behavioural disorders such as anxiety, aggression, and cognitive dysfunction. Some might be upregulated and some downregulated, so you might experience heightened serotonin responses. Finasteride (Proscar) blocks the conversion of testosterone to dihydrotestosterone, the major male sex hormone found in cells of the prostate. Mens Health and Fertility Lifestyle Information: Weill Cornell Medicine Center. Post-finasteride syndrome: An emerging clinical problem: Neurobiology of Stress, May 2020. Post-finasteride syndrome | The BMJ Are you sensitive to dietary fats and have greasy stool with fat floating on the surface of the water after pitching a loaf? Finasteride use in young males is a potential risk for their sexual health. The use of Finasteride (Proscar) for the prevention of cancer is limited since it only prevents the harmless type of prostate cancer (the SKY Stage.) Id love to help you out. Kaplan-Marans E, Sandozi A, Martinez M, Lee J, Schulman A, Khurgin J. Don't listen to bad doctors who tell you its all in your head. The patient needs to know that, and to be able to say, Im stopping now. Even if the incidence of persistent sexual adverse events is 3% to 5%, which may be viewed as a small number, approximately 900,000 to 1.5 million men would suffer persistent sexual and psychiatric adverse events. For the time being, as a general rule: Refrain from prescribing oral finasteride to a patient with a personal history of depression, sexual dysfunction, or fertility problems. Transdermal substitution of dihydrotestosterone led to an improvement in sexual symptoms in two placebo-controlled studies. These constellations of symptoms constitute the basis for PFS in individuals predisposed to epigenetic susceptibility. 2021 Dec 13;54(4):422-434. doi: 10.1055/s-0041-1739254. [PFS] appears to occur in sensitive individuals, even if exposed to small doses and for short periods, and symptoms can persist for long periods. @MariaUloko discusses #postfinasteridesyndrome and #pssd. Androsterone both allopregnanolone and androsterone are potent GABA agonists, so might substitute to a degree for each other. Its not to be used without medical supervision. Concern regarding adverse effects of finasteride is increasing. You can argue with the theoretician but you cant argue with the anecdotal stories of successful recovery. My private email list for written articles, exclusive offers, sales & more: http://bit.ly/2mtASGW https://gorillamind.com . Do not take finasteride for hair lossDo not take finasteride for any purposeFor many years, Public Citizens Health Research Group has classified both [Proscar and Propecia] as Do Not Use because their benefits do not outweigh their adverse effects. The https:// ensures that you are connecting to the So thankful to have found this article. Based on currently available data, the use of 5-reductase inhibitors in patients with a history of depression, sexual dysfunction or infertility must be carefully and individually evaluated. Yuck. Post-finasteride syndrome wasnt reported in clinical studies, but it has been reported since the drug was approved. Careers. [A]pproximately 30 million young men, worldwide, would be prescribed finasteride or dutasteride to treat male pattern hair loss. Thats the responsibility of the doctor who prescribes the medication, or the pharmacist who supplies it. I have seen some cases of post-finasteride-syndrome that do not revert to anything. HCG increased my anxiety. But Nobody Warned Me about Finasteride! In addition, there is a recognized conglomerate of sexual side effects accompanied by neuropsychiatric effects including depression that have been grouped into a term known as post-finasteride syndrome. Aging Male. Seems that almost half of urologists instruct their patients to stop finasteride! Im not beholden to trT. Finasteride is not one of my first recommendations due to its possible known side effects. Post-Finasteride Syndrome (PFS): A Surmountable Challenge for Skin Appendage Disord. So combining progesterone + DHEA and allopregnanolone + DHT can be is even better. But now I would not feel comfortable recommending Propecia to a young, sexually active man. [T]hese data indicate the urgent need for high-quality clinical trials, with long-term follow up, specifically addressing sexual function and mood disorders. DHEA potently increases androsterone levels, and that is how its thought to lower anxiety. [F]inasteride is associated with common adverse health effects in women with long-term treatment for androgenetic alopecia, such as irregular menstrual cycle, aromatase disorder, high cholesterol, heavy menstrual bleeding and induced DNA damage. Regulatory Effects of Thai Rice By-Product Extracts from. If cortisol is low in blood tests, then you can focus on increasing that, but if cortisol is low in saliva tests but high in blood tests, focus on calming the adrenals. I am on the transcrotal cream. Have you tried NGF boosting supplements such as lions mane or even Cerebrolysin? HTX Urology website, December 2019. Agreed. Based on data of this study, I will strong[ly] recommend to my patients [that] using finasteride has the probability of suicidehigher than 22% than no use. The longer they take it, the greater the risk of experiencing persistent side effects, including after theyve stopped. I have a good friend who, with the best of intentions, told me about his positive hair plug experience and wanted to make [sure] I didnt miss my window of opportunity for treatment. Epub 2016 Jan 13. New Information about Post Finasteride Syndrome (PFS) Taking Propecia or Proscar to Prevent Hair Loss is Associated with Depression, Anxiety, and Sexual Problems: National Center for Health Research website, 2021. What happens if you get side ef. No Fun. It can prevent hair loss and decrease prostate enlargement, but not surprisingly, it can also suppress sexual function. Baldness Medication Can Cause Permanent Erection Problems (English translation): De Volkskrant, February 15, 2019. These symptoms are very rare, but once you have them, its forever. Its Monday, which means its time for a poll! Whats happening to the progesterone if I try HCG? To help with sleep I am also I use Magnesium , Lemon Balm, Taurine, Theanine and other sleep-aid herbs . After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. Definitely see this. This site needs JavaScript to work properly. The effect of finasteride on dry eye disease, Investigative Ophthalmology & Visual Science: June 2022. Now two months after stopping Dudasteride, my twitches and brain zaps are now greatly diminshed, insomnia is still a problem though. "The presence of severe and persistent side effects caused by the treatment of an aesthetic problem raises great concern for the clinician. Blocking 5 alpha-reductase to any degree in the brain is a crapshoot. I train a lot, heavy resistance, HIIT, play sport, drink very little. Moreover, the effects persisted long after the drug had been discontinued.[T]hey then called in men with PFS, took skin from the penis and found that the density of androgen receptors in men with PFS was about twice that of those without. If I work out too much or my job is extra stressful I become symptomatic. And it must be mentioned that there are cases in which these functions are irreversibly impaired, which means there is no recovery after discontinuation of use. I find this amazing article. Meanwhile, professional organizations may provide educational materials for physicians in order to increase their awareness regarding the scope of these persistent catastrophic adverse effects of finasteride and dutasteride. Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens, Psychoneuroendocrinology, October 2016. I am 29 now and started at 22. Accessibility The .gov means its official. [Propecia] has the sexual side effects, like erectile dysfunction, which can affect men for years. Post-finasteride syndrome is a legit thing. Post Finasteride Syndrome is a HOAX! : r/tressless - Reddit In my opinion, I do not recommend using finasteride for the treatment of hair loss as its side effects are more dangerous. Diagnostic Criteria - The Post-Finasteride Syndrome Foundation So thats all gone in many men, just because of finasteride. Some recommend andractim, available in Europe (and online). I think we need to put the [PCPT] trial concerns to rest. sharing sensitive information, make sure youre on a federal By reducing DHT so drastically, effects can occur in the genital tissues and in the brain. Here we evaluate the scientific and clinical evidence in the contemporary medical literature to address the very fundamental question: Is PFS a real clinical condition caused by finasteride use or are the reported symptoms only incidentally associated with but not caused by finasteride use? There was circumstantial evidence that PFS may represent a delusional disorder of the somatic type, possibly on a background of a histrionic personality disorder, which would explain the refractoriness of the condition and a high degree of suggestibility. 100% agree. A Comment on the Post-Finasteride Syndrome - PMC The most notable finding was that adverse effects persisted in each of the domains, indicating the possible presence of a post-finasteride syndrome., Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride: American Journal of Mens Health, June 13, 2014. Response (via Twitter) to the top 20 adverse reactions to finasteride filed with the FDA: April 23, 2021. There are serious side effects that need to be considered! We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment.The most frequent sexual symptomswere loss of penis sensitivity (87.3%), decreased ejaculatory force (82.3%), and low penile temperature (78.5%). They also have problems with sex drive. Reggie told me that sometimes he got confused for no reason and he felt tired all the time. Clipboard, Search History, and several other advanced features are temporarily unavailable. Pharmacological Management of Pattern Hair Loss. Aim: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. I know @CanesDavid agrees. progesterone -dihydroprogesterone (a very important neuroactive steroid and precursor to allopregnanolone), deoxycorticosterone dihydrodeoxycorticosterone (DHDOC), cortisol 5-dihydrocortisol (for the deactivation of cortisol), aldosterone 5-dihydroaldosterone, which increases the excretion of salt, the opposite of aldosterone, dry skin or thinning of the skin, weight gain, elevated glucose and lipids and worsening of insulin sensitivity(, diminished libido, erectile dysfunction, ejaculatory complaints, penile discomfort, loss of scrotal sensitivity, scrotal discomfort, loss of pubic hair, increased sperm density and, Alcohol (not a long term or good strategy really). And I have to use huge amounts of testosterone to overcome this drug. To date, the PFS Foundation has identified 118 such professionals who have published scientific findings and/or voiced opinions on causative links between finasteride and PFS. Thanks for the positive feedback and Im glad its helpful. While finasteride may reduce incidence of BPH and/or change the incidence or type of prostate cancer one gets, it also seems to increase the risk of self harm and/or suicide in both younger and older men. If a patient absolutely wants to take finasteride, he must sign a form acknowledging that he has been informed about the side effects and is willing to accept them. Chronic insomnia , I am now taking Trazodone which helps me get to sleep, I also have myoclonic twitches and brain zaps while trying to fall asleep and my auditory system is super sensitive any small noise at night makes my me jump even when wearing ear plugs. Etc Etc Sexual dysfunction and suicidal ideation that appears to result from [finasteride] are important adverse effects. It is frequently marketed as androgen deprivation therapy for treatment for male pattern baldness. Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next? Frontiers in Endocrinology, May 2020. Medications Most Commonly Associated with Erectile Dysfunction: The Journal of Urology, May 15, 2022. Would you like email updates of new search results? I have blood and hormones test results if u want. I wanted to take a minute to talk to you about post-finasteride syndrome since more and more men are coming in with complaints after taking finasteride. Statement via Twitter to fellow clinicians: June 5, 2022. Use of 5ARIs for treatment of AGA may lead to persistent sexual, genitourinary, physical, psycho-cognitive, and anti-androgenic sequelae even after cessation of 5ARI therapy Two subjects (8%) committed suicide during or after the study. Accordingly, Health Canada and the UAE Ministry of Health recommend that companies that produce products containing [finasteride] add the above-mentioned warning to the internal leaflet of their products. He Became Depressed and His Sex Drive Disappeared. Every dermatologist has their own way of treating the condition. 2012 Nov;9(11):2927-32. doi: 10.1111/j.1743-6109.2012.02846.x. Post-finasteride syndrome: a surmountable challenge for clinicians. Bile also acts as an anti-bacterial and anti-microbial substance which keeps the gut clean and prevents SIBO and SIFO.