Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines NOTE: This sheet is a summary. Heres a sample meal plan thats packed with nutritious foods just for. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. Common Its recommended that you take 400 international units of vitamin D and 1,000 milligrams (mg) of calcium with Prolia. You may wonder how Prolia compares with the alternative drug Reclast. Check with your doctor if you have more questions about these drugs. Denosumab Injection: MedlinePlus Drug Information Its important to tell your doctor if you have serious or ongoing side effects. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. Tell your doctor if you become pregnant. If your dizziness doesnt go away or becomes severe, talk with your doctor. Continue reading. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. But if you think youre having a medical emergency, call 911 or your local emergency number. Side effects are possible with Prolia use, but in most cases they go away after a while. They can tell you more about benefits and risks of Prolia and Forteo. Your doctor can help you decide which drug is better for your needs. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. With low BMD your bone tissues have less mineral, which means they become weaker. What should be considered before taking Prolia? Instead, it belongs to a different group of medications called biologics. But weight gain may occur with other medications you take or other health conditions you have. There arent any studies that have compared these two drugs to each other. Prolia isnt known to cause any harmful interactions with alcohol. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. Advertising on our site helps support our mission. * For more information about this side effect, see Side effect specifics below. However, drinking too much alcohol may raise your risk of falling. You should also talk with them if you have any serious side effects during Prolia treatment. Be sure to talk with your doctor about your health history before you take Prolia. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. Based on your dental history, your doctor can discuss with you the risks of using Prolia. Talk with your doctor if youd like to know about taking generic denosumab. Call your doctor for medical advice about side effects. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. Learn strategies you can use today. Call your doctor for instructions if you miss a dose or miss an appointment for your Prolia injection. Since different people With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. Osteoporosis medications and medication-related osteonecrosis of the jaw. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. The list below may not include all possible serious side effects of the drug. WebProlia is used to treat osteoporosis in women after menopause and in men, and in people Cleveland Clinic is a non-profit academic medical center. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Prolia (denosumab) | Dosing Below are answers to some commonly asked questions about Prolia. These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). Youll get Prolia injections from a healthcare professional once every 6 months. You may need to stop using the medicine for a short time. And be sure to let your doctor know about all the medications youre currently taking. And if you have osteoporosis, falling could increase your risk of fractures. Theyll discuss with you other treatments to help prevent bone loss. Prolia Frequently Asked Questions (FAQs) These supplements help to prevent a low calcium level while youre taking Prolia. Some people may have dental or jaw-related issues with Prolia use. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Prolia pregnancy and breastfeeding warnings. Last updated on Feb 8, 2023. Prolia can cause many serious side effects. Patients should not stop Prolia treatment without first consulting your If youre concerned about weight gain with Prolia, talk with your doctor. Do not shake the prefilled syringe. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. Nausea can sometimes be a symptom of severe constipation. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. Tell them if you have any scheduled dental work coming up. Special care may be needed. * In this article, we use the terms male and female to refer to someones sex assigned at birth. Prolia is a monoclonal antibody. Policy. Osteoporosis Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. Call your doctor right away if you have an allergic reaction to Prolia. Its important to discuss all your concerns with your doctor. Also tell them if you smoke, drink alcohol, or use illegal drugs. Every 6 months youll get another dose of Prolia. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. This list doesnt include all possible mild side effects of the drug. Different individuals may respond to medication in different ways. You might wonder how Prolia and the drug Xgeva compare. For more information, you can refer to the drugs prescribing information. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. (Hint: it's not just. Your doctor will recommend the dosage of Prolia thats right for you. Its possible that some of Prolias side effects may be long term, but theyre rare. If you have a low calcium level, you should not take Prolia. Use of the term female in this article refers to sex assigned at birth. * Sex and gender exist on spectrums. All rights reserved. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. What is the most important information I should know about Prolia? This may help to protect healthy cells from damage. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. * Sex and gender exist on spectrums. But Zometa contains the active drug zoledronic acid. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). You Doing so will help to prevent dental problems. If youd like to learn more about Prolia, talk with your doctor or pharmacist. Will my fracture risk come back if I stop Prolia treatment? Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. Available for Android and iOS devices. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. Last medically reviewed on November 29, 2022. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis. Denosumab (Prolia) for postmenopausal osteoporosis If your Prolia treatment is stopped, talk to your doctor about other medicine that For more information about how these medications compare with each other, ask your doctor. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. You should always consult your doctor or another healthcare professional before taking any medication. Do not use denosumab if you are pregnant. You should also ask your doctor if Prolia is safe for you if you have or have had: Additionally, let your doctor know if youre pregnant or breastfeeding. What's the difference between Prolia and Reclast? These problems may include: Your risk for mouth-related side effects may be higher if you have problems with your teeth. If youre pregnant or breastfeeding, or considering either, talk with your doctor. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. Prolia and Forteo are both used to treat osteoporosis. To learn more about this side effect, see Side effect specifics below. Find out which foods can help. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. (Vitamin D helps your body absorb calcium.) After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. If you have any questions about Prolias side effects, talk with your doctor. Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. But hair loss has been reported by people who have taken Prolia since then. If you are a healthcare professional, click "I Agree" to continue. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin It is given by a health care professional in a hospital or clinic setting. The Prolia is making my leg bones and jaw bones hurt. Prolia should not be used during pregnancy. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. You may report side effects to FDA at 1-800-FDA-1088. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Learn more details about some of the side effects that Prolia may cause. It works with your immune system to help prevent bone loss. You may have questions about Prolia and your treatment plan. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. Drug class: miscellaneous bone resorption inhibitors. What do I need to be aware of if I need a tooth extraction while Im using Prolia? But theyre each effective in treating osteoporosis and preventing bone loss. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. (A placebo is a treatment with no active drug.). Youll receive Prolia doses from a healthcare professional. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. You do not give Prolia to yourself. Your risk for some health conditions increases when you are postmenopausal. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. Studies of Prolia didnt report weight gain as a side effect of the drug. When estrogen levels drop, your risk of osteoporosis goes up. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. If you have low blood calcium, it may get worse during treatment. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Other drugs that have the same active ingredients (e.g. What should I know about Prolia vs. Zometa? If youre concerned about side effects with Prolia, talk with your doctor. Prolia comes as a solution thats given as an injection under your skin. Osteoporosis is a condition that causes your bones to become thin and weak. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. Serious side effects from Prolia can occur, but they arent common. Web You will receive Prolia 1 time every 6 months. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. But certain choices and habits accelerate the process. Are there lifestyle changes that can help my osteoporosis. To help prevent low calcium, your healthcare provider may also Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. It is created by eHealthMe based on reports of 8,432 people who take Prolia and Calcium from the FDA, and is updated regularly. Try to avoid being around people who are sick. Specifically, Prolia is a monoclonal antibody (a lab-made protein). And in my mind, that's no different than scheduling a visit to the dentist twice a year. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). Prolia side effects: What you should know - Medical Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. They can help answer any questions you have about side effects from taking the drug. Talk to your health care professional or pharmacist for more information. Talk with your doctor about the best options for treating your condition. The fractures may require surgeries, take several months to heal, or both. Stopping Prolia doesnt cause withdrawal symptoms. Copyright 2023 Elsevier Inc. All Rights Reserved. Your doctor or health care professional may order blood tests and other tests to see how you are doing. such as inflammation of your skin (dermatitis), rash, and eczema have been reported. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium. WebNow that Im taking Prolia, do I still need calcium and vitamin D? The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Talk with your doctor or health care professional about your birth control options while taking this medicine. It is important not to miss your dose. Continue reading, While there are no known drug interactions between Prolia (generic name: denosumab) and alcohol, but you should check with your doctor first before you drink. Calcium supplements may help support bone and teeth health. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. (2022). But it can increase your risk of serious health problems, such as heart attack. Also describe any vitamins, herbs, or supplements you use. Your side effects from Prolia may also vary depending on your gender. Prolia: Side Effects, Alternatives, How It's Administered, Yoga is an excellent way to manage symptoms of osteoporosis. Dietary calcium is considered safe, but too much calcium in the form of supplements might have some health risks. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. Osteopenia For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. (Chlorhexidine helps kill germs in your mouth.). Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. Prolia is injected under the skin. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Continue reading, Prolia (denosumab) has not been associated with weight gain in clinical studies. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below. You should always consult your doctor or another healthcare professional before taking any medication. (Biosimilars are like generic drugs. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Its a, Forteos active ingredient is teriparatide. Before you start Prolia treatment, your doctor will examine the inside of your mouth. Use effective birth control while using denosumab and for at least 5 months after your last dose. Some people have developed unusual fractures in their thigh bone. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Talk with your doctor before starting Prolia treatment. you can take. If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. Healthline Media does not provide medical advice, diagnosis, or treatment. Various types of osteoporosis medications are available. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. If you miss a dose of Prolia, you should receive your injection as soon as you can. Brush and floss your teeth regularly while receiving this medication. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. But its not clear whether this side effect occurred in clinical studies. But doing so can cause more bone breakdown and increase your risk for bone fractures. This is the drugs mechanism of action. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. They do this by slowing the loss of minerals such as calcium from your bones. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). that's no different than scheduling a visit to the dentist twice a year. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Breastfeeding. Its used to lower the risk of bone fractures in people with certain other conditions. While you are using Prolia, you should not receive Xgeva, another brand of denosumab. What should I know about Prolia vs. Evenity? have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. Medication Guide. This information is intended only for U.S. healthcare professionals. Over time, Prolia can reduce bone loss and make your bones stronger. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. They can explain the risks and benefits of this drug. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. And you should continue using birth control for at least 5 months after stopping Prolia. Prolia is also available in a biosimilar form. You can learn more about how we ensure our content is accurate and current by reading our. But its believed that these side effects are rare. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. Patient testimonials represent individual experiences with Prolia. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. This aids in keeping your calcium level within the recommended range. Starting an osteoporosis drug? Here So treatment with the drug requires you to take daily calcium and vitamin D supplements. Also, hair loss may be related to other medications you take or health conditions you have. The drug could cause your calcium level to drop too low. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.)